ea0029p46 | Adrenal cortex | ICEECE2012
Akerstrom T.
, Ahmad T.
, Hellman P.
, Bjorklund P.
Background: Adrenocortical carcinomas (ACC) are rare tumors with an incidence of 12 per million. Although rare, it is an aggressive endocrine cancer with poor prognosis. As of today there is no reliable diagnostic biomarker to distinguish benign tumors from malignant tumors. Global changes in DNA methylation and DNA promoter hypermethylation are important events in tumorigenesis. Promoter hypermethylation can cause silencing of tumour suppressor genes or lead to abnormal...